No single test can diagnose osteoarthritis. Most doctors use a combination of the following methods to diagnose the disease and rule out other conditions:
Clinical history: The doctor begins by asking the patient to describe the symptoms, and when and how the condition started. Good doctor-patient communication is important. The doctor can give a better assessment if the patient gives a good description of pain, stiffness, and joint function, and how they have changed over time. It also is important for the doctor to know how the condition affects the patient's work and daily life. Finally, the doctor also needs to know about other medical conditions and whether the patient is taking any medicines.
Physical examination: The doctor will check the patient's general health, including checking reflexes and muscle strength. Joints bothering the patient will be examined. The doctor will also observe the patient's ability to walk, bend, and carry out activities of daily living.
X rays: Doctors take x rays to see how much joint damage has been done. X rays of the affected joint can show such things as cartilage loss, bone damage, and bone spurs. But there often is a big difference between the severity of osteoarthritis as shown by the x ray and the degree of pain and disability felt by the patient. Also, x rays may not show early osteoarthritis damage, before much cartilage loss has taken place.
Other tests: The doctor may order blood tests to rule out other causes of symptoms. Another common test is called joint aspiration, which involves drawing fluid from the joint for examination.
It usually is not difficult to tell if a patient has osteoarthritis. It is more difficult to tell if the disease is causing the patient's symptoms. Osteoarthritis is so common--especially in older people--that symptoms seemingly caused by the disease actually may be due to other medical conditions. The doctor will try to find out what is causing the symptoms by ruling out other disorders and identifying conditions that may make the symptoms worse. The severity of symptoms in osteoarthritis is influenced greatly by the patient's attitude, anxiety, depression, and daily activity level.
How Is Osteoarthritis Treated?
Most successful treatment programs involve a combination of treatments tailored to the patient's needs, lifestyle, and health. Osteoarthritis treatment has four general goals:
• Improve joint care through rest and exercise.
• Maintain an acceptable body weight.
• Control pain with medicine and other measures.
• Achieve a healthy lifestyle.
Treatment Approaches to Osteoarthritis
• Weight control
• Rest and joint care
• Pain relief techniques
• Alternative therapies
Osteoarthritis treatment plans often include ways to manage pain and improve function. Such plans can involve exercise, rest and joint care, pain relief, weight control, medicines, surgery, and nontraditional treatment approaches.
Exercise: Research shows that exercise is one of the best treatments for osteoarthritis. Exercise can improve mood and outlook, decrease pain, increase flexibility, improve the heart and blood flow, maintain weight, and promote general physical fitness. Exercise is also inexpensive and, if done correctly, has few negative side effects. The amount and form of exercise will depend on which joints are involved, how stable the joints are, and whether a joint replacement has already been done. (See Be a Winner! Practice Self-Care and Keep a "Good-Health Attitude."
On the Move: Fighting Osteoarthritis With Exercise
You can use exercises to keep strong and limber, extend your range of movement, and reduce your weight.Some different types of exercise include the following:
Strength exercises: These can be performed with exercise bands, inexpensive devices that add resistance.<BR>
Aerobic activities: These keep your lungs and circulation systems in shape.<BR>
Range of motion activities: These keep your joints limber.<BR>
Agility exercises: These can help you maintain daily living skills.<BR>
Neck and back strength exercises: These can help you keep your spine strong and limber.<BR>
Ask your doctor or physical therapist what exercises are best for you. Ask for guidelines on exercising when a joint is sore or if swelling is present. Also, check if you should (1) use pain-relieving drugs, such as analgesics or anti-inflammatories (also called NSAIDs), to make exercising easier, or (2) use ice afterwards.
Rest and joint care: Treatment plans include regularly scheduled rest. Patients must learn to recognize the body's signals, and know when to stop or slow down, which prevents pain caused by overexertion. Some patients find that relaxation techniques, stress reduction, and biofeedback help. Some use canes and splints to protect joints and take pressure off them. Splints or braces provide extra support for weakened joints. They also keep the joint in proper position during sleep or activity. Splints should be used only for limited periods because joints and muscles need to be exercised to prevent stiffness and weakness. An occupational therapist or a doctor can help the patient get a properly fitting splint.
Nondrug pain relief: People with osteoarthritis may find nondrug ways to relieve pain. Warm towels, hot packs, or a warm bath or shower to apply moist heat to the joint can relieve pain and stiffness. In some cases, cold packs (a bag of ice or frozen vegetables wrapped in a towel can relieve pain or numb the sore area. (Check with a doctor or physical therapist to find out if heat or cold is the best treatment.) Water therapy in a heated pool or whirlpool also may relieve pain and stiffness. For osteoarthritis in the knee, patients may wear insoles or cushioned shoes to redistribute weight and reduce joint stress.
Weight control: Osteoarthritis patients who are overweight or obese need to lose weight. Weight loss can reduce stress on weight-bearing joints and limit further injury. A dietitian can help patients develop healthy eating habits. A healthy diet and regular exercise help reduce weight.
Medicines: Doctors prescribe medicines to eliminate or reduce pain and to improve functioning. Doctors consider a number of factors when choosing medicines for their patients with osteoarthritis. Two important factors are the intensity of the pain and the potential side effects of the medicine. Patients must use medicines carefully and tell their doctors about any changes that occur.
The following types of medicines are commonly used in treating osteoarthritis:
• Acetaminophen: Acetaminophen is a pain reliever (for example, Tylenol*) that does not reduce swelling. Acetaminophen does not irritate the stomach and is less likely than nonsteroidal anti-inflammatory drugs (NSAIDs) to cause long-term side effects. Research has shown that acetaminophen relieves pain as effectively as NSAIDs for many patients with osteoarthritis.
Warning: People with liver disease, people who drink alcohol heavily, and those taking blood- thinning medicines or NSAIDs should use acetaminophen with caution.
* Note: Brand names included in this booklet are provided as examples only. Their inclusion does not mean they are endorsed by the National Institutes of Health or any other Government agency. Also, if a certain brand name is not mentioned, this does not mean or imply that the product is unsatisfactory.
• NSAIDs (nonsteroidal anti-inflammatory drugs): Many NSAIDs are used to treat osteoarthritis. Patients can buy some over the counter (for example, aspirin, Advil, Motrin IB, Aleve, ketoprofen). Others require a prescription. All NSAIDs work similarly: they fight inflammation and relieve pain. However, each NSAID is a different chemical, and each has a slightly different effect on the body.
Side effects: NSAIDs can cause stomach irritation or, less often, they can affect kidney function. The longer a person uses NSAIDs, the more likely he or she is to have side effects, ranging from mild to serious. Many other drugs cannot be taken when a patient is being treated with NSAIDs because NSAIDs alter the way the body uses or eliminates these other drugs. Check with your health care provider or pharmacist before you take NSAIDs in addition to another medication. Also, NSAIDs sometimes are associated with serious gastrointestinal problems, including ulcers, bleeding, and perforation of the stomach or intestine. People over age 65 and those with any history of ulcers or gastrointestinal bleeding should use NSAIDs with caution.
COX-2 inhibitors: Several new NSAIDs--valdecoxib (Bextra) and celecoxib (Celebrex)--from a class of drugs known as COX-2 inhibitors are now being used to treat osteoarthritis. These medicines reduce inflammation similarly to traditional NSAIDs, but they cause fewer gastrointestinal side effects. However, these medications occasionally are associated with harmful reactions ranging from mild to severe. (See Current Research.)
• Other medications: Doctors may prescribe several other medicines for osteoarthritis, including the following:
Topical pain-relieving creams, rubs, and sprays (for example, capsaicin cream), which are applied directly to the skin.
Mild narcotic painkillers, which--although very effective--may be addictive and are not commonly used.
Corticosteroids, powerful anti-inflammatory hormones made naturally in the body or manmade for use as medicine. Corticosteroids may be injected into the affected joints to temporarily relieve pain. This is a short-term measure, generally not recommended for more than two or three treatments per year. Oral corticosteroids should not be used to treat osteoarthritis.
Hyaluronic acid, a medicine for joint injection, used to treat osteoarthritis of the knee. This substance is a normal component of the joint, involved in joint lubrication and nutrition.
Questions To Ask Your Doctor or Pharmacist About Medicines
• How often should I take this medicine?
• Should I take this medicine with food or between meals?
• What side effects can I expect?
• Should I take this medicine with the other prescription medicines I take?
• Should I take this medicine with the over-the-counter medicines I take?
Most medicines used to treat osteoarthritis have side effects, so it is important for people to learn about the medicines they take. Even nonprescription drugs should be checked. Several groups of patients are at high risk for side effects from NSAIDs, such as people with a history of peptic ulcers or digestive tract bleeding, people taking oral corticosteroids or anticoagulants (blood thinners), smokers, and people who consume alcohol. Some patients may be able to help reduce side effects by taking some medicines with food. Others should avoid stomach irritants such as alcohol, tobacco, and caffeine. Some patients try to protect their stomachs by taking other medicines that coat the stomach or block stomach acids. These measures help, but they are not always completely effective.
Surgery: For many people, surgery helps relieve the pain and disability of osteoarthritis. Surgery may be performed to:
• Remove loose pieces of bone and cartilage from the joint if they are causing mechanical symptoms of buckling or locking
• Resurface (smooth out) bones
• Reposition bones
• Replace joints
Surgeons may replace affected joints with artificial joints called prostheses. These joints can be made from metal alloys, high-density plastic, and ceramic material. They can be joined to bone surfaces by special cements. Artificial joints can last 10 to 15 years or longer. About 10 percent of artificial joints may need revision. Surgeons choose the design and components of prostheses according to their patient's weight, sex, age, activity level, and othe
r medical conditions.
The decision to use surgery depends on several things. Both the surgeon and the patient consider the patient's level of disability, the intensity of pain, the interference with the patient's lifestyle, the patient's age, and occupation. Currently, more than 80 percent of osteoarthritis surgery cases involve replacing the hip or knee joint. After surgery and rehabilitation, the patient usually feels less pain and swelling, and can move more easily.
Nontraditional Approaches: Among the alternative therapies used to treat osteoarthritis are the following:
• Acupuncture: Some people have found pain relief using acupuncture (the use of fine needles inserted at specific points on the skin). Preliminary research shows that acupuncture may be a useful component in an osteoarthritis treatment plan for some patients. (See Current Research.)
• Folk remedies: Some patients seek alternative therapies for their pain and disability. Some of these alternative therapies have included wearing copper bracelets, drinking herbal teas, and taking mud baths. While these practices are not harmful, some can be expensive. They also cause delays in seeking medical treatment. To date, no scientific research shows these approaches to be helpful in treating osteoarthritis.
• Nutritional supplements: Nutrients such as glucosamine and chondroitin sulfate have been reported to improve the symptoms of people with osteoarthritis, as have certain vitamins. Additional studies are being carried out to further evaluate these claims. (See Current Research.)
Health Professionals Who Treat Osteoarthritis
Many types of health professionals care for people with osteoarthritis:
• Primary care physicians. Doctors who treat patients before they are referred to other specialists in the health care system.
• Rheumatologists. Medical doctors who specialize in treating arthritis and related conditions that affect joints, muscles, and bones.
• Orthopaedists. Doctors who specialize in treatment of and surgery for bone and joint diseases.
• Physical therapists. Health professionals who work with patients to improve joint function.
• Occupational therapists. Health professionals who teach ways to protect joints, minimize pain, and conserve energy.
• Dietitians. Health professionals who teach ways to use a good diet to improve health and maintain a healthy weight.
• Nurse educators. Nurses who specialize in helping patients understand their overall condition and implement their treatment plans.
• Physiatrists (rehabilitation specialists). Doctors who help patients make the most of their physical p
• Licensed acupuncture therapists. Health professionals who reduce pain and improve physical functioning by inserting fine needles into the skin at various points on the body.
• Psychologists. Health professionals who help patients cope with difficulties in the home and workplace resulting from their medical conditions.
• Social workers. Professionals who assist patients with social challenges caused by disability, unemployment, financial hardships, home health care, and other needs resulting from their medical conditions.
<b>Be a Winner! Practice Self-Care and Keep a "Good-Health Attitude"
People with osteoarthritis can enjoy good health despite having the disease. How? By learning self-care skills and developing a "good-health attitude."
Self-care is central to successfully managing the pain and disability of osteoarthritis. People have a much better chance of having a rewarding lifestyle when they educate themselves about the disease and take part in their own care. Working actively with a team of health care providers enables people with the disease to minimize pain, share in decisionmaking about treatment, and feel a sense of control over their lives. Research shows that people with osteoarthritis who take part in their own care report less pain and make fewer doctor visits. They also enjoy a better quality of life.
Self-Management Programs Do Help
People with osteoarthritis find that self-management programs help them
• Understand the disease
• Reduce pain while remaining active
• Cope physically, emotionally, and mentally
• Have greater control over the disease
• Build confidence in their ability to live an active, independent life.
Self-Help and Education Programs: Three kinds of programs help people learn about osteoarthritis, learn self-care, and improve their good-health attitude. These programs include:
• Patient education programs
• Arthritis self-management programs
• Arthritis support groups
These programs teach people about osteoarthritis, its treatments, exercise and relaxation, patient and health care provider communication, and problem solving. Research has shown that these programs have clear and long-lasting benefits.
Exercise: Regular physical activity plays a key role in self-care and wellness. Two types of exercise are important in osteoarthritis management. The first type, therapeutic exercises, keep joints working as well as possible. The other type, aerobic conditioning exercises, improve strength and fitness, and control weight. Patients should be realistic when they start exercising. They should learn how to exercise correctly, because exercising incorrectly can cause problems.
Most people with osteoarthritis exercise best when their pain is least severe. Start with an adequate warmup and begin exercising slowly. Resting frequently ensures a good workout. It also reduces the risk of injury. A physical therapist can evaluate how a patient's muscles are working. This information helps the therapist develop a safe, personalized exercise program to increase strength and flexibility.
Many people enjoy sports or other activities in their exercise program. Good activities include swimming and aquatic exercise, walking, running, biking, cross-country skiing, and using exercise machines and exercise videotapes.
People with osteoarthritis should check with their doctor or physical therapist before starting an exercise program. Health care providers will suggest what exercises are best for you, how to warm up safely, and when to avoid exercising a joint affected by arthritis. Pain medications and applying ice after exercising may make exercising easier.
Exercises for Osteoarthritis
People with osteoarthritis should do different kinds of exercise for different benefits to the body.
Body, Mind, Spirit: Making the most of good health requires careful attention to the body, mind, and spirit. People with osteoarthritis must plan and develop daily routines that maximize their quality of life and minimize disability. They also need to evaluate these routines periodically to make sure they are working well.
Good health also requires a positive attitude. People must decide to make the most of things when faced with the challenges of osteoarthritis. This attitude--a good-health mindset--doesn't just happen. It takes work, every day. And with the right attitude, you will achieve it.
Enjoy a "Good-Health Attitude"
• Focus on your abilities instead of disabilities.
• Focus on your strengths instead of weaknesses.
• Break down activities into small tasks that you can manage.
• Incorporate fitness and nutrition into daily routines.
• Develop methods to minimize and manage stress.
• Balance rest with activity.
• Develop a support system of family, friends, and health professionals.
The leading role in osteoarthritis research is played by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), within the National Institutes of Health (NIH). The NIAMS funds many researchers across the United States to study osteoarthritis. It has established a Specialized Center of Research devoted to osteoarthritis. Also, many researchers study arthritis at NIAMS Multipurpose Arthritis and Musculoskeletal Diseases Centers and Multidisciplinary Clinical Research Centers. These centers conduct basic, laboratory, and clinical research aimed at understanding the causes, treatment options, and prevention of arthritis and musculoskeletal diseases. Center researchers also study epidemiology, health services, and professional, patient, and public education. The NIAMS also supports multidisciplinary clinical research centers that expand clinical studies for diseases like osteoarthritis.
For years, scientists thought that osteoarthritis was simply a disease of "wear and tear" that occurred in joints as people got older. In the last decade, however, research has shown that there is more to the disorder than aging alone. The production, maintenance, and breakdown of cartilage, as well as bone changes in osteoarthritis, are now seen as a series or cascade of events. Many researchers are trying to discover where in that cascade of events things go wrong. By understanding what goes wrong, they hope to find new ways to prevent or treat osteoarthritis. Some key areas of research are described below.
Animal Models: Animals help researchers understand how diseases work and why they occur. Animal models help researchers learn many things about osteoarthritis, such as what happens to cartilage, how treatment strategies might work, and what might prevent the disease. Animal models also help scientists study osteoarthritis in very early stages before it causes detectable joint damage.
Diagnostic Tools: Some scientists want to find ways to detect osteoarthritis at earlier stages so that they can treat it earlier. They seek specific abnormalities in the blood, joint fluid, or urine of people with the disease. Other scientists use new technologies to analyze the differences between the cartilage from different joints. For example, many people have osteoarthritis in the knees or hips, but few have it in the ankles. Can ankle cartilage be different? Does it age differently? Answering these questions will help us understand the disease better.
Genetics Studies: Researchers suspect that inheritance plays a role in 25 to 30 percent of osteoarthritis cases. Researchers have found that genetics may play a role in approximately 40 to 65 percent of hand and knee osteoarthritis cases. They suspect inheritance might play a role in other types of osteoarthritis, as well. Scientists have identified a mutation (a gene defect) affecting collagen, an important part of cartilage, in patients with an inherited kind of osteoarthritis that starts at an early age. The mutation weakens collagen protein, which may break or tear more easily under stress. Scientists are looking for other gene mutations in osteoarthritis. Recently, researchers found that the daughters of women who have knee osteoarthritis have a significant increase in cartilage breakdown, thus making them more susceptible to disease. In the future, a test to determine who carries the genetic defect (or defects) could help people reduce their risk for osteoarthritis with lifestyle adjustments.
Tissue Engineering: This technology involves removing cells from a healthy part of the body and placing them in an area of diseased or damaged tissue in order to improve certain body functions. Currently, it is used to treat small traumatic injuries or defects in cartilage, and, if successful, could eventually help treat osteoarthritis. Researchers at the NIAMS are exploring three types of tissue engineering. The two most common methods being studied today include cartilage cell replacement and stem cell transplantation. The third method is gene therapy.
• Cartilage cell replacement: In this procedure, researchers remove cartilage cells from the patient's own joint and then clone or grow new cells using tissue culture and other laboratory techniques. They then inject the newly grown cells into the patient's joint. Patients with cartilage cell replacement have fewer symptoms of osteoarthritis. Actual cartilage repair is limited, however.
• Stem cell transplantation: Stem cells are primitive cells that can transform into other kinds of cells, such as muscle or bone cells. They usually are taken from bone marrow. In the future, researchers hope to insert stem cells into cartilage, where the cells will make new cartilage. If successful, this process could be used to repair damaged cartilage and avoid the need for surgical joint replacements with metal or plastics.
• Gene therapy: Scientists are working to genetically engineer cells that would inhibit the body chemicals, called enzymes, that may help break down cartilage and cause joint damage. In gene therapy, cells are removed from the body, genetically changed, and then injected back into the affected joint. They live in the joint and protect it from damaging enzymes.
Comprehensive Treatment Strategies: Effective treatment for osteoarthritis takes more than medicine or surgery. Getting help from a variety of care professionals often can improve patient treatment and self-care. (See Health Professionals Who Treat Osteoarthritis.) Research shows that adding patient education and social support is a low-cost, effective way to decrease pain and reduce the amount of medicine used.
Exercise plays a key part in comprehensive treatment. Researchers are studying exercise in greater detail and finding out just how to use it in treating or preventing osteoarthritis. For example, several scientists have studied knee osteoarthritis and exercise. Their results included the following:
• Strengthening the thigh muscle (quadriceps) can relieve symptoms of knee osteoarthritis and prevent more damage.
• Walking can result in better functioning, and the more you walk, the farther you will be able to walk.
• People with knee osteoarthritis who were active in an exercise program feel less pain. They also function better.
Research has shown that losing extra weight can help people who already have osteoarthritis. Moreover, overweight or obese people who do not have osteoarthritis may reduce their risk of developing the disease by losing weight.
Using NSAIDs: Many people who have osteoarthritis have persistent pain despite taking simple pain relievers such as acetaminophen. Some of these patients take NSAIDs instead. Health care providers are concerned about long-term NSAID use because it can lead to an upset stomach, heartburn, nausea, and more dangerous side effects, such as ulcers.
Scientists are working to design and test new, safer NSAIDs. One example currently available is a class of selective NSAIDs called COX-2 inhibitors. Traditional NSAIDs prevent inflammation by blocking two related enzymes in the body called COX-1 and COX-2. The gastrointestinal side effects associated with traditional NSAIDs seems to be associated mainly with blocking the COX-1 enzyme, which helps protect the stomach lining. The new selective COX-2 inhibitors, however, primarily block the COX-2 enzyme, which helps control inflammation in the body. As a result, COX-2 inhibitors reduce pain and inflammation but are less likely than traditional NSAIDs to cause gastrointestinal ulcers and bleeding. However, research shows that some COX-2 inhibitors may not protect against heart disease as well as traditional NSAIDs, so check with your doctor if you have concerns.
Drugs to Prevent Joint Damage: No treatment actually prevents osteoarthritis or reverses or blocks the disease process once it begins. Present treatments just relieve the symptoms. Researchers are looking for drugs that would prevent, slow down, or reverse joint damage. One experimental antibiotic drug, doxycycline, may stop certain enzymes from damaging cartilage. The drug has shown some promise in clinical studies, but more studies are needed. Researchers also are studying growth factors and other natural chemical messengers. These potential medicines may be able to stimulate cartilage growth or repair.
Acupuncture: During an acupuncture treatment, a licensed acupuncture therapist inserts very fine needles into the skin at various points on the body. Scientists think the needles stimulate the release of natural, pain-relieving chemicals produced by the brain or the nervous system. Researchers are studying acupuncture treatment of patients who have knee osteoarthritis. Early findings suggest that traditional Chinese acupuncture is effective for some patients as an additional therapy for osteoarthritis, reducing pain and improving function.
Nutritional Supplements: Nutritional supplements are often reported as helpful in treating osteoarthritis. Such reports should be viewed with caution, however, since very few studies have carefully evaluated the role of nutritional supplements in osteoarthritis.
• Glucosamine and chondroitin sulfate: Both of these nutrients are found in small quantities in food and are components of normal cartilage. Scientific studies on these two nutritional supplements have not yet shown that they affect the disease. They may relieve symptoms and reduce joint damage in some patients, however. The National Center for Complementary and Alternative Medicine at the NIH is supporting a clinical trial to test whether glucosamine, chondroitin sulfate, or the two nutrients in combination reduce pain and improve function. Patients using this therapy should do so only under the supervision of their doctor, as part of an overall treatment program with exercise, relaxation, and pain relief.
• Vitamins D, C, E, and beta carotene: The progression of osteoarthritis may be slower in people who take higher levels of vitamin D, C, E, or beta carotene. More studies are needed to confirm these reports.
Hyaluronic Acid: Injecting this substance into the knee joint provides long-term pain relief for some people with osteoarthritis. Hyaluronic acid is a natural component of cartilage and joint fluid. It lubricates and absorbs shock in the joint. The Food and Drug Administration (FDA) approved this therapy for patients with osteoarthritis of the knee who do not get relief from exercise, physical therapy, or simple analgesics. Researchers are presently studying the benefits of using hyaluronic acid to treat osteoarthritis.
Estrogen: In studies of older women, scientists found a lower risk of osteoarthritis in women who had used oral estrogens for hormone replacement therapy. The researchers suspect having low levels of estrogen could increase the risk of developing osteoarthritis. Additional studies are needed to answer this question.